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1 CLINICAL STUDIES Investigators assessed the efficacy and safety of the combination product for the treatment of uncontrolled type II diabetes in two phase 3 clinical studies

One was for the incisional pain experiment and the other was for the formalin test experiment

Metformin has been associated with reduced vitamin B12 absorption through effects on calcium-dependent membrane action in the terminal ileum, which may be relevant for patients on chronic metformin therapy