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If bruising is large (larger than a quarter), painful beyond tenderness, or does not fade within two weeks, consult a healthcare provider

Consensus sequence One approach that has been taken is to design vaccine antigens that are enriched for conserved T and B-cell epitopes either as a consensus sequence (which is the closest natural circulating sequence to a bioinformatically calculated consensus) or as a string of epitopes taken out of their natural context within the viral protein (Fig

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This increases the risk that: Products may be contaminated or mislabeled Adverse events may not be monitored or reported Patients may be misled about efficacy 4

This knowledge will be informative for the design of vaccines against other infectious agents

References Stier H