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Homocysteine has been shown to block the activation of insulin receptors, resulting in decreased glucose uptake by cells, hyperglycemia, and compensatory hyperinsulinemia.2 Elevated blood homocysteine levels were significantly related to rates of type 2 diabetes among 5,000 adult patients enrolled in 25 multinational prospective and case-control studies

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10.1021/bi00171a002 34 JiX.TordovaM.O'DonnellR.ParsonsJ

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Central nervous system involvement in diabetic neuropathy