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How do GLP-1s affect motivation and reward in the brain

The parasympathetic innervation originates from the dorsal motor nucleus of the vagus (DMV) in the medulla (108), while the sympathetic supply derives from the prevertebral ganglia (109)

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Potential Benefits Appetite regulation: Stronger, longer-lasting satiety that helps reduce calorie intake [7] [8]

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Eating large meals before or shortly after injection increases nausea risk, but true vomiting occurs in only 5-10% of users and is usually temporary