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In the Phase 2b VESPER-1 trial, dosing was given as 28 weekly doses to characterize dose-response, with the intent to transition to monthly dosing in Phase 3

1 Each step is a fresh adjustment, and the nausea tends to track the steps rather than the calendar

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The trick is knowing which signals mean "normal adjustment" and which ones mean "this dose is too high and needs to change." Here is how to tell the difference

If you cannot, something is wrong

More specifically, AT2 cells lose regenerative capacity during ILD, leading to their substitution by progenitor airway cells invading the alveoli 169