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Histone extraction from human articular cartilage for the study of epigenetic regulation in osteoarthritis

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Furthermore, excessive oxidative stress byproducts act as inflammatory amplifiers. They promote the secretion of proinflammatory factors including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 by initiating signaling pathways including NF-B and MAPK, and simultaneously suppress the expression of anti-inflammatory factors including IL-10 and transforming growth factor beta (TGF-) (Phull et al., 2018

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