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The hydroxyl radical is one of the most reactive and potentially damaging free radicals in human biology

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Interaction of TNF with TNFRSF1A leads to the recruitment of various proteins, including RIPK1, TRADD, baculoviral IAP repeat containing 2 (BIRC2/CIAP1) or baculoviral IAP repeat containing 3 (BIRC3/CIAP2), and TNF receptor-associated factor, which form a membrane-bound multimeric protein complex on the cytoplasmic side [123]

Initial studies that looked at anti-IL-33 agents were done in other sites of allergy beside asthma, specifically in atopic dermatitis and peanut allergy