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Biomolecules 9 (11), 655

Abbreviations ACSL1: Acyl-CoA Synthetase Long-Chain Family Member 1 ADRB2: Adrenoceptor Beta 2 AKT: AKT Serine/Threonine Kinase ALT: Alanine Aminotransferase AMPK: Liver Adenosine Monophosphate-Activated Protein Kinase ASK1: Apoptosis Signal-regulating Kinase 1 AST: Aspartate Aminotransferase ATF4: Activating Transcription Factor 4 BCA: Bicinchoninic Acid Assay BCL3: BCL3 Transcription Coactivator BSA: Bovine Serum Albumin BP: BiologicalProcess -arrestin2: Beta-Arrestin 2 CC: CellularComponent cAMP: Cyclic Adenosine Monophosphate CDS: CellDynamicSimulation C/EBP-: CCAAT/Enhancer-Binding Protein Alpha cGAS-STING: cyclic GMP-AMP synthase-stimulator of interferon genes DAMPs: Damage-Associated Molecular Patterns DAPI: 46-Diamidino-2-phenylindole DEGs: Differentially Expressed Genes DNL: De Novo Lipogenesis DT: Decision Tree ECL: Enhanced Chemiluminescence EGR1: Early Growth Response 1 eIF2: eukaryotic Initiation Factor 2 alpha ERK: Extracellular Signal-Regulated Kinase FADD: Fas Associated Via Death Domain FBG: Fasting Blood Glucose FFA: Free Fatty Acids FAS: FAS Cell Surface Death Receptor FOS: AP-1 Transcription Factor Subunit FXR: Farnesoid X Receptor Agonist GF-1: Transforming Growth Factor-beta 1 GBM: GradientBoostingMachine GEO: Gene Expression Omnibus Database Gi: G inhibitory protein GLM: GeneralizedLinearModel GLP-1: Glucagon-Like Peptide-1 Receptor Agonist GLU: Glucose GSDME: Gasdermin E GSH: glutathione GO: Gene Ontology HMGB1: High Mobility Group Box 1 HE: Hematoxylin and Eosin Staining HepG2: Hepatoma Cell Line G2 HSCs: Hepatic Stellate Cells HRP: Horseradish Peroxidase IGT: Impaired Glucose Tolerance IL-1: Interleukin-1 Beta IL-6: Interleukin-6 IF: Immunofluorescence Staining IR: Insulin Resistance JNK: c-Jun N-terminal Kinase KEGG: Kyoto Encyclopedia of Genes and Genomes KNN: K-NearestNeighbors LASSO: LeastAbsoluteShrinkageandSelectionOperator LDL-C: Low-Density Lipoprotein Cholesterol mTOR: Mechanistic Target of Rapamycin mTORC1: Mechanistic Target of Rapamycin Complex 1 MAP3K8: Mitogen-Activated Protein Kinase Kinase Kinase 8 MDA: Malondialdehyde MF: MolecularFunction MyD88: Myeloid Differentiation Primary Response 88 NAFLD: Non-Alcoholic Fatty Liver Disease MASLD: Metabolic dysfunction-associated steatotic liver disease NASH: Non-Alcoholic Steatohepatitis NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells NLRP3: NACHT LRR and PYD domains-containing protein 3 NNET: NeuralNetwork OTCC: Optimal Temperature Cutting Compound Pal: palmatine PERK: PKR-like Endoplasmic Reticulum Kinase PI3K: Phosphatidylinositol 3-Kinase PBS: Phosphate Buffered Saline PKA: cAMP-dependent Protein Kinase PDE4: Phosphodiesterase 4 PPAR-: Peroxisome Proliferator-Activated Receptor Gamma PUMA: p53 Upregulated Modulator of Apoptosis PVDF: Polyvinylidene Fluoride RIPA: Radioimmunoprecipitation Assay Buffer ROC: Receiver Operating Characteristic Curve RF: RandomForest SOD: Superoxide Dismutase Sem: Semaglutide Smad3: Mothers Against Decapentaplegic Homolog 3 SREBP-1c: Sterol Regulatory Element-Binding Protein 1c STZ: Streptozotocin ssGSEA: Single-Sample Gene Set Enrichment Analysis SVM: SupportVectorMachine TBA: Total Bile Acids T-C: Total Cholesterol TAK1: TGF--Activated Kinase 1 T-G: Triglycerides TLR4: Toll-Like Receptor 4 TNF-: Tumor Necrosis Factor Alpha T2DM: Type 2 Diabetes Mellitus WB: Western Blot XGB: eXtremeGradientBoosting References Younossi, Z

Liver Health: Methionine, inositol, and choline are essential for liver health and function

A: Frequency depends on your individual health goals and your providers recommendation

The appropriate dosage of MSM can vary depending on your age, health status, and the specific condition being treated

Many individuals achieve excellent results on moderate doses while avoiding the increased side effects that higher doses produce