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Using GLP-1 RAs in conjunction with other glucose-lowering or cardiovascular medications can significantly enhance treatment effectiveness, reduce side effects, and better meet the diverse needs of different patients

Semaglutide lowers the production of glucagon in the liver

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Its labeling also includes cardiovascular and kidney-risk reduction in appropriate patients

These changes lead to the accumulation of damaged proteins in myocytes, thereby reducing their ability to adapt to physiological stress and increasing the risk of heart disease in old age

(PubMed) Hurwitz BE, Klaus JR, Llabre MM, et al