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Protopine reduces the reuptake of 5-HT and NE via inhibiting the transporter (67)

10.4014/jmb.2203.03022 324 ZackularJ

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This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation

For example, some patients cycle off of their therapy once theyve reached a milestone