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As a lead compound, 23 (IC 50 = 3.73 M) demonstrates potential for further studies (Figure 4)

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They have also demonstrated that rat brain microvascular endothelial cells can rapidly uptake fluorescence-labeled GLP-1, the event can be blunted with the utilization of the GLP-1R antagonist Exendin (939)

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Still, results should be carefully generalized to cases of background kidney dysfunction or when using drugs with narrow therapeutic index." Dr