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The same disparity between rich animal data and sparse human trials characterizes many peptide compounds, partly because the economics of pharmaceutical development disfavor compounds that cannot be patented in their natural form

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Despite its evocative name, its precise mechanism remains incompletely understood, which is exactly what makes it an enduring subject of experimental investigation into sleep, stress and neuroprotection

Second, instead of mediating the cutting of mRNA transcripts, ASOs can also be designed to target and hybridize with inhibitory elements in the 5 UTR region of the mRNA transcript

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