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Drugs which inhibit CYP 3A4 (e.g., ketoconazole, itraconazole, ritonavir, indinavir, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids

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Using the attributable fractions of lung cancer, already estimated (Table 2) by age group and sex, and the relative risks for lung cancer in smokers from the American cohort (Table 1), the above formula enables calculation of P e for each age/sex group