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We measured the withdrawal threshold at 2 and 6 h and 4 and 7 days after the incision

Longer uninterrupted dosing is not recommended because receptor sensitivity can diminish without cycling

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Weight-Based Dosing Guidelines Under 160 lbs : 300 mcg daily 160-200 lbs : 400 mcg daily (standard protocol) 200-250 lbs : 500 mcg daily Over 250 lbs : 500 mcg daily (may require extended cycling) Heavier individuals often require higher doses due to increased adipose tissue mass and potentially altered peptide distribution

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