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Additionally, fibrotic ECM suppresses antifibrotic miRNAs (e.g.,miR-29), perpetuating collagen synthesis (127)

The proportion of TPA-stimulated ROS-forming PMN ( Figure 5F ) fluctuated nonspecifically over time until 9 h pi and dropped rapidly to a nadir at 12 h pi , when only 88% of PMN could be stimulated, before maintaining the baseline level until the end of the trial

123 Besides, oxidative stress conditions also increase the innately high IDH1 expression, and IDH1 silencing significantly enhances cell sensitivity to cancer chemotherapy, radiotherapy, and photodynamic therapy by reducing NADPH

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