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To elucidate the protective effect of sitagliptin (i.e., the specificity of DDP4 inhibitor) on N2a cells, the experimental study was categorized into four groups: Na2 cell only (i.e., control group) (group I), N2a cell treated by H 2 O 2 (group II), N2a cell treated by H 2 O 2 and sitagliptin (group III), N2a cell + H 2 O 2 + sitagliptin + LY-294002 (i.e., a specific PI3K inhibitor) (group IV)

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This form of carnitine is uniquely characterised by the presence of an acetyl group , which facilitates the absorption of the molecule in the intestine, allowing it to cross the blood-brain barrier, the protective barrier separating the bloodstream from the brain

54% of patients achieved more than 15% weight loss compared to 6% on placebo

Kamel R, Leroy J, Vandecasteele G, Fischmeister R (2023) Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure