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This scoping review was carried out in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews) guidelines

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Addressing depression and obesity simultaneously, with two medications that work through complementary mechanisms and do not interfere with each other pharmacologically, represents one of the more elegant treatment combinations available today

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Close monitoring is essential, with clear parameters established for escalating to dose reduction or discontinuation if symptoms worsen

If youve had ongoing nausea or other gastrointestinal issues on Wegovy 2.4 mg or 7.2 mg HD, the safer landing point is Mounjaro 2.5 mg rather than 5 mg