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Brodkey , MD, FCCM, Associate Professor, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI

Observing heterogenous exposure definitions, we also evaluated the impact of omitting observations that used ever-chewing tobacco as the exposure group, keeping only observations that compared current tobacco chewers to nontobacco chewers, and the impact of potential regional differences in chewing tobacco definitions by restricting data to only that from Asian countries, the region with the highest number of chewing tobacco users

Snake River Air Cured Twist Chewing tobacco is rope-like with braided tobacco leaves and is made from air-cured tobacco

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Studies have further provided evidence that tobacco smoke can serve as a mutagen and an aneugen of germ cell/spermatozoa (Marchetti et al