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Ohkubo Y, Kishikawa H, Araki E et al (1995) Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

The cardiovascular, bone density, and cognitive benefits typically outweigh the risks for this population under proper physician supervision

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[1] [2] Suspected side effects should be reported via the MHRA Yellow Card scheme, particularly if they are severe, unusual, or not listed in the patient information leaflet

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Common early side effects include mild nausea, reduced appetite (the intended effect), and occasional constipation or diarrhea