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Additionally, we examined the gut microbiome and metabolic changes in Nrf2-KO mice, uncovering further factors contributing to their heightened vulnerability

Mucolytic- breaks down mucus and enhances clearance of the airways

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Specifically, apoA-I binds to ABCA1 and activates phosphatidylcholine lipases, which activate PKC leading to the movement of cellular cholesterol from intracellular stores to the plasma membrane for efflux, as well as PKC-mediated phosphorylation of ABCA1, which increases the transporters stability and efflux activity (782-784)

the current state of mechanistic evidence and its limitations