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In some instances, the endolymph-compatible and/or perilymph-compatible formulations or compositions described herein cause minimal disturbance to the environment of the inner ear and cause minimum discomfort (e.g., vertigo and/or nausea) to a mammal upon administration

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Additionally, because of its high oxygen consumption, rich supply of polyunsaturated fatty acids, and exposure to visible light, the retina is particularly susceptible to oxidative stress caused by hyperglycemia [42]