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Even more impressively, during the SURMOUNT-1 trial, study volunteers who used the highest dose (15mg) of tirzepatide lost as much as 21% of their body weight-equivalent to an average of 52 pounds

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The phase III clinical trial of eprotirome was ultimately halted after only six weeks due to concurrent toxicology studies in dogs demonstrating the adverse effects of eprotirome on canine cartilage [81]

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