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Newer approaches are more accurately demonstrating real-world cost-effectiveness of an intervention based on true human use

Caldeira-Brant AL, Martinelli LM, Marques MM, Reis AB, Martello R, Almeida FRCL, Chiarini-Garcia H (2020) A subpopulation of human Adark spermatogonia behaves as the reserve stem cell

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In the liver, the accumulation of lipids is thought to impair mitochondrial function, thus reducing fatty acid oxidation and increasing the production of reactive oxygen species (ROS) that trigger lipid peroxidation, DNA damage, and apoptosis

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