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In vitro experiments have consistently demonstrated that 6-OHDA induces ferroptosis in SH-SY5Y neuroblastoma cell models

In a poor nutritional state, GSH reserves become easily exhausted and hepatic glucouronidation is stunted, leading to decreased levels of available GSH that would otherwise be scavenged for formation of reactive metabolites in phase I of APAP metabolism

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It is interesting that patients who underwent sedation and ventilation presented fewer cognitive disorders, an effect attributed to reduction of stress by sedation and/or increased oxygenation due to ventilation (46)