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The rate of color development is directly related to the ALP activity present in the serum sample

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In addition, the availability of folates and B12 in their activated forms, i.e., methylfolate and methylcobalamin, may increase their actual metabolic suitability by escaping the common genetic variants of the respective activating enzymes Methylene TetraHydroFolate Reductase (MTHFR) and Methionine Synthase Reductase (MTRR) [15, 16]

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Failure of anti-TNF treatment in patients with rheumatoid arthritis: the pros and cons of the early use of alternative biological agents

doi: 10.3233/JPD-161040