It is important for patients and practitioners to understand that 'investigational' or 'research' status does not equate to safety, efficacy, or regulatory approval for human use outside of controlled clinical trial settings
Liver findings included lower liver weight, reduced triglyceride content and less severe histological features of steatosis and inflammatory-cell infiltration in treated mice
(2025) trial included both sexes
In a trial of patients with T2DM and BMI 27 kg/m2 or more receiving semaglutide injection for weight management, retinal disorders were reported by 6.9% of patients treated with semaglutide 2.4 mg/week, 6.2% of patients treated with semaglutide 1 mg/week, and 4.2% of patients treated with placebo
Ann Med Surg (Lond) 2024;86:3180-3
Research involving multiple metabolic-, mitochondrial-, or stimulant-related compounds may warrant additional caution and individualized evaluation in experimental settings