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The appetite-suppressing effect of pancreatic peptide YY (peptide tyrosine tyrosine) is well known, and initial clinical studies are underway with long-acting YY peptide analogs as monotherapy and in combination with GLP-1 receptor agonists for obesity treatment [115]

SOURCE Novo Nordisk Canada Inc

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Ozempic is approved for this indication in the USA, EU, Canada, Japan, and Australia 2,3,4,5,6

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Although comparisons between tirzepatide and higher doses of dulaglutide (e.g., 4.5 mg) have yet to be done, these data argue against the concept that GIP coagonism can reduce the risk of GI adverse events