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Doig, K

Hauser RA, Olanow CW, Kieburtz KD, Neale A, Resburg C, Maya U, et al

Notably, sleep-deprived mice treated with GHK had lower inflammation compared to both sleep-deprived and control mice in the CA3 region of the hippocampus

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However, from a translational standpoint, targeting cytoskeletalmitochondrial interactions is challenging because systemic microtubule modulators or actin-targeting drugs have narrow therapeutic windows and substantial toxicity, particularly for proliferating cells such as bone marrow progenitors and intestinal epithelium