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5 Nicotine enters the hair through your blood, and from exposure to smoke, causing a rise in cell-damaging free radical activity

This process is potentially dangerous to cells, as peroxidation of mitochondrial phospholipids may affect the integrity of permeability transition pores (PTPs) and disaggregate complexes I and III of the respiratory chain, thereby enhancing electron leakage within the mitochondrial intermembrane space 5,6

Some plans periodically request evidence of continued use, clinical benefit, medical supervision, or adherence to treatment recommendations

This is a recognized limitation that has spurred research into combination approaches with exercise and potentially anabolic agents

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