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The opportunity is significant given Indias large metabolic disease burden 77 M diabetics (9095% Type-2) and nearly 180M overweight or obese adults

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SIRT3 is a histone deacetylase located in the mitochondria that responds to RS and protects cells from genotoxic damage mediated by oxidative processes, thereby reducing cell apoptosis mediated by genotoxins and OS, maintaining mitochondrial homeostasis by deacetylating substrates in an NAD + -dependent manner [143]