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FIGURE 6 Cellular Validation of the Specificity of GPX4 Activator To further evaluate the selectivity and specificity of compound 102 in a cellular context, we employed the cellular thermal shift assay (CETSA

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4A and B), while the transcription of diap1-lacZ was reduced (Fig

B., Dubey, R

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3.3 Mechanism of spirocyclization Detailed mechanistic studies of spirodiazaselenuranes and structural characterization were carried out by using 77 Se NMR spectroscopy