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And without the continued downward trajectory that motivated continued use, exploring alternatives with different mechanisms becomes an appealing strategy to break through stalled progress

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The laboratory was blinded to treatment and placebo groups

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:688698

It directly neutralises reactive oxygen species (ROS) and serves as the cofactor for glutathione peroxidase, the enzyme that converts hydrogen peroxide to water

For me, the concern is around how this type of rebound effect leads to learned helplessness, a mental state in which a person gets conditioned to believe they cant control or change a situation, so they stop trying even when opportunities for change are available