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Amitriptyline should be started at a low dose and slowly titrated up to the desired effect if tolerated

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Older adults Age-related considerations include potentially slower response times requiring longer protocols, importance of medical supervision given likely concurrent health conditions, possible interactions with age-related medications, and conservative dosing approaches initially

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Wang et al., 2018) propose, SD may affect neuronal function in a different and more global manner leading to activation of pathways unrelated to plasticity (Naidoo, 2012