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Introduction Constipation is one of the most persistent side effects of GLP1 medications, affecting approximately 24 percent of patients on semaglutide 2.4 mg in the STEP 1 trial (Wilding et al., New England Journal of Medicine , 2021)

PMID: 16702333 | DOI: 10.1093/jn/136.6.1636S [13] Kumar P, Osahon OW, Vides DB, et al

As part of its mechanism, it does two crucial things

B complex, on the other hand, is a combination of all eight B vitamins, including thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, and vitamin B12

Someone traveling for work, for example, may notice their constipation gets worse simply because their routine, water intake, and meal timing have all shifted at once, even without a dose change

Combination therapy is possible under strict medical supervision but carries cardiovascular risks because phentermine raises heart rate and blood pressure while semaglutide alters glucose and heart rate regulation