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Both medications accumulate to steady state within 3-4 weeks of consistent weekly injections, though tirzepatide's slightly shorter half-life means it clears more rapidly if doses are delayed

Exceptions might exist for competitive athletes with specific goals and medical supervision, but general users should view doses above 300 mcg with caution

J Neuropsychiatry Clin Neurosci 37:A6-101

However, because semaglutide changes how your body processes food and oral medications, there are several important timing and side-effect considerations to keep in mind

Your body prioritizes clearing alcohol over burning fat, and research shows the metabolic shift can linger for hours to the next day after drinking

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