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The ability of Epitalon to permeate the cell membrane and enter the nucleus has been demonstrated [20], thus suggesting that its activity may be associated with cytoplasmic and nuclear components

Studies suggest that by displacing FOXO4, the peptide releases p53 to translocate to the cytoplasm and mitochondria, where it activates Bax/Bak pore formation and caspase-mediated apoptosis

Studies have shown that peptides are able to inhibit lipase activity and bind to bile acids, which allows for its ability to lower cholesterol levels

[DOI] [PubMed] [Google Scholar] 201.Drmic D., Kolenc D., Ilic S., Bauk L., Sever M., Zenko Sever A., Luetic K., Suran J., Seiwerth S., Sikiric P

10.1016/j.npep.2008.02.001 23 BryantN

Gently swirl or rotate the vial to dissolve the peptide