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Potential off-target effects can be suspected when the experimental results are opposite to what was expected but they are less likely pursued when the obtained results are consistent with the expectation

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Vitamin B6 but only 3 times a week, instead of daily, as he used to Attia worries about data showing that too much B6 can lead to neuropathy, or nerve damage

No published controlled trial has studied combining tirzepatide and retatrutide in humans

Use in pregnancy appears safe, but use during breastfeeding is not recommended