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13 Distinguishing the skeletal effects of insulin from those of IGF-1 in vivo is complicated by the fact that most cell types express both IR and IGF-1R, as well as IR/IGFIR hybrid receptors, which can be cross-activated by the others receptors ligand

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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig