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This dynamic regulation allows active Vitamin D to intervene during the later stages of T cell activation, where VDR binds to Vitamin D response elements (VDREs) in the genome, reshaping the T cell transcriptional landscape and modulating cytokine expression, migratory behavior, and metabolic programming [160,161,162]

[PMC free article: PMC9847480] [PubMed: 36356613] 38

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The respective macrocycles were characterized in vitro by surface plasmon resonance (SPR) and all exhibited strong affinity to the Met ectodomain ( K D =219 nM

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