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It typically develops with age and most frequently occurs in the hands, hips and knees

doi:10.1371/journal.pone.0313082 Haro M, Grate G, Hernndez JL, et al

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Bender, M

Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X et al (2014) Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

All patients were extubated when they were able to maintain spontaneously a PaO2/FIO2 ratio of more than 400