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In China, gastric and liver cancers are the second and third leading causes of death among patients with malignant tumors [226, 227], and deaths due to digestive system cancers are among the highest worldwide [228, 229]

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Before CoQ 10 emerged as a ferroptosis suppressor, it was primarily viewed as an essential electron carrier in the mitochondrial electron transport chain (ETC), shuttling electrons from complexes I/II to complex III to maintain oxidative phosphorylation 18