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The exact mechanisms explaining these findings are not completely understood, but there is some evidence that agonist-induced internalization of the two receptors for GLP-1 and GIP differs markedly

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[79] When used together with alpha-blockers, no benefit was reported in short-term trials, but in a longer-term study (34 years) there was a greater reduction in BPH progression to acute urinary retention and surgery than with either agent alone, especially in people with more severe symptoms and larger prostates

The component-level dose-response curves in published research apply only to the doses studied in those references

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