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Across the 68-week STEP 1-3 trials, semaglutide-treated participants, as compared to those who received placebo, did not show an increased risk of developing moderately severe symptoms of depression or of suicidal thoughts or behavior

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At 15 mg (maximum dose) The highest approved maintenance dose produces the most weight loss but also the most side effects, including fatigue at 7% incidence

PEGylation is used to increase molecular size and is often explored for its potential to extend peptide persistence in experimental systems