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This DMF concentration didnt reduce cell viability under non-BSO pretreatment condition and reduced cell viability less than 5% under BSO pretreatment condition (Supplementary Figure S2)

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Targeting mitochondrial oxidative stress and dysfunction for AILI treatment In the injury process of APAP hepatotoxicity, mitochondrial proteins are the main targets of NAPQI, compared with total protein-binding in hepatocytes, including housekeeping protein, glutathione peroxidase (GPx) and adenosine triphosphate (ATP) synthase -subunit [95]