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With the gradual progression of atherosclerotic plaques, atherosclerosis will induce angina pectoris, or cerebral ischemia, leading to severe clinical manifestations such as heart failure, myocardial infarction (MI), cerebral infarction and lower limb ischemia and amputation [2]

Position sizing matters across the three, because the risk profiles are not interchangeable

10.1016/j.bbamcr.2012.02.019 77 PerissinottoE.BujaA.MaggiS.EnziG.ManzatoE.ScafatoE.et al (2010)

The presentation can vary considerably, with some individuals experiencing subtle symptoms whilst others develop dramatic, life-threatening manifestations

That microdose is 2.5-5.0mg for tadalafil and 2.5mg for vardenafil

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