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This apparent discrepancy may reflect the complex relationship between gene expression and protein synthesis, which is influenced by post-transcriptional regulation, mRNA stability, translational efficiency, and protein turnover rates

Glycemic control, assessed by HbA1c, showed a trend toward lower values in the GLP-1 RA group (6.1% vs 7.0%, p = 0.08), which may have contributed to improved tear film stability and production, although this difference was not statistically significant and cannot solely explain the ocular surface differences

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Conducted by Eli Lilly, these trials involved over 2,000 adults and showcased an average of up to 28.3% body weight loss at higher dosages