Great news here: GLP-1 agonist medications are generally considered safe
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The affected peptides aren't permanently confined to Category 2
DOI:10.1097/psy.0b013e3181d9523c
LACTIC ACIDOSIS A very rare complication of metformin therapy is lactic acidosis (53)
Metformin has a mild inhibitory effect on complex I of oxidative phosphorylation, has antioxidant properties, and activates both glucose-6-phosphate dehydrogenase (G6PD