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The tissue it is supposed to calm simply does not have enough receptors to hear the signal
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Good absorption: Abdominal absorption is reliable and consistent
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doi: 10.3233/JHD-160226 29 ChoudharyC.KumarC.GnadF.NielsenM
(PubMed) Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR
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