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B.S., M.S.-R., P.V.T.F., N.M., and J.S.-R., critically reviewed the manuscript
Its primary mechanism is suppressing NF-kB activation, a master switch that controls inflammatory gene expression throughout the body
The four endorsed Thursday have not
Impairments in neuronal survival mediated by HMGB1 are believed to be closely associated with the glycolytic pathway, as evidenced by the mitigation of these adverse effects through treatment with the glycolysis inhibitor 2-DG [194]
This combination activates lethal autophagy dependent on AMPK activation (AMPK kinase is activated by a decrease in intracellular ATP and a change in the ATP:AMP ratio), enhancing the sensitivity of radiation-resistant cells to cell death and efficacy of radiotherapy 29,77 (Figure 3)