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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

In addition, other antioxidant systemsincluding GSH, thioredoxin (Trx), and peroxiredoxinsare highly active in CRC cells and collectively reinforce their defense against oxidative stress [34, 37, 38]

(2019) S-geranylgeranyl-L-glutathione is a ligand for human B-cell confinement receptor P2RY, Nature , 567 , 244-248, doi: Ramsay, E